• Latest
  • Trending
  • All
  • Featured Urology
  • Female Urology
  • Urologic Oncology
  • What is Urology?
  • Pediatric Urology
  • Urology

‘Big data’ technique improves monitoring of kidney transplant patients

September 8, 2020
Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

November 14, 2022
New treatment can more than double life expectancy for people with prostate cancer: doctor

New treatment can more than double life expectancy for people with prostate cancer

November 14, 2022
Study finds that use of yoga app can reduce urinary incontinence

Study finds that use of yoga app can reduce urinary incontinence

November 9, 2022
Urinary Incontinence: Types and Treatments

Urinary Incontinence: Types and Treatments

November 9, 2022
Low Rates of PSA Screening Linked to Increase in Metastatic Prostate Cancer

Low Rates of PSA Screening Linked to Increase in Metastatic Prostate Cancer

November 4, 2022
Can Erectile Dysfunction Drugs Reduce Dementia Risk?

Can Erectile Dysfunction Drugs Reduce Dementia Risk?

November 4, 2022
New PSA test examines protein structures to detect prostate cancers

New PSA test examines protein structures to detect prostate cancers

November 2, 2022
A better way to image metastatic prostate cancer

A better way to image metastatic prostate cancer

November 2, 2022
Newly discovered protein may protect kidney cells from injury

Newly discovered protein may protect kidney cells from injury

November 2, 2022
A person’s diet, acidity of urine may affect susceptibility to UTIs

A person’s diet, acidity of urine may affect susceptibility to UTIs

November 2, 2022
Award-winning agent developed for prostate cancer diagnosis and treatment

Award-winning agent developed for prostate cancer diagnosis and treatment

November 2, 2022
New treatment for polycystic kidney disease

New treatment for polycystic kidney disease

November 2, 2022
Wednesday, November 16, 2022
Urology Today
  • Home
  • Featured Urology
    Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

    Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

    Study finds that use of yoga app can reduce urinary incontinence

    Study finds that use of yoga app can reduce urinary incontinence

    Urinary Incontinence: Types and Treatments

    Urinary Incontinence: Types and Treatments

    Low Rates of PSA Screening Linked to Increase in Metastatic Prostate Cancer

    Low Rates of PSA Screening Linked to Increase in Metastatic Prostate Cancer

    Kidney failure impacts survival of sepsis patients

    Kidney failure impacts survival of sepsis patients

    Urine-based test improves on PSA for detecting prostate cancer

    Urine-based test improves on PSA for detecting prostate cancer

    Unemployment linked to rise in prostate cancer deaths

    Unemployment linked to rise in prostate cancer deaths

    Unemployment linked to rise in prostate cancer deaths

    Advanced viral gene therapy eradicates prostate cancer in preclinical experiments

    prostate cancer

    Recurrence of prostate cancer detected earlier with innovative PSMA-ligand PET/CT

    Two major studies strengthen case for prostate cancer drug before chemotherapy

    Two major studies strengthen case for prostate cancer drug before chemotherapy

    Trending Tags

    • Donald Trump
    • Future of News
    • Climate Change
    • Market Stories
    • Election Results
    • Flat Earth
  • Lifestyle
    • All
    • Female Urology
    • Male Urology
    • Pediatric Urology
    Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

    Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

    Study finds that use of yoga app can reduce urinary incontinence

    Study finds that use of yoga app can reduce urinary incontinence

    Urinary Incontinence: Types and Treatments

    Urinary Incontinence: Types and Treatments

    New PSA test examines protein structures to detect prostate cancers

    New PSA test examines protein structures to detect prostate cancers

    A better way to image metastatic prostate cancer

    A better way to image metastatic prostate cancer

    Award-winning agent developed for prostate cancer diagnosis and treatment

    Award-winning agent developed for prostate cancer diagnosis and treatment

    New treatment for polycystic kidney disease

    New treatment for polycystic kidney disease

    Urine-based test improves on PSA for detecting prostate cancer

    Urine-based test improves on PSA for detecting prostate cancer

    Unemployment linked to rise in prostate cancer deaths

    Advanced viral gene therapy eradicates prostate cancer in preclinical experiments

    Two major studies strengthen case for prostate cancer drug before chemotherapy

    Two major studies strengthen case for prostate cancer drug before chemotherapy

    Trending Tags

    • Golden Globes
    • Mr. Robot
    • MotoGP 2017
    • Climate Change
    • Flat Earth
No Result
View All Result
Urology Today
No Result
View All Result
Home Urology / Nephrology News

‘Big data’ technique improves monitoring of kidney transplant patients

by Urology Today
September 8, 2020
in Urology / Nephrology News
0
491
SHARES
1.4k
VIEWS
Share on FacebookShare on Twitter

A new data analysis technique radically improves monitoring of kidney patients, according to a University of Leeds-led study, and could lead to profound changes in the way we understand our health.

The research, published in the journal PLoS Computational Biology, provides a way of making sense out of the huge number of clues about a kidney transplant patient’s prognosis contained in their blood.

By applying sophisticated “big data” analysis to the samples, scientists were able to crunch hundreds of thousands of variables into a single parameter indicating how a kidney transplant was faring.

That allowed the team of physicists, chemists and clinicians to predict poor function of a kidney after only two days in cases that may not previously have been detected as failing until weeks after transplant.

The extra few days would give doctors a better chance to intervene to save a transplant and improve patient recovery periods. In some cases, the team were able to predict failure from patients’ blood samples taken before the transplant operation.

Dr Sergei Krivov, research fellow in the University of Leeds’ Astbury Centre for Structural Molecular Biology, who led the research, said: “If you put a blood sample through Nuclear Magnetic Resonance analysis you get a very large number of different parameters that vary with the outcome for a patient.

“These are vital clues but, if you have got thousands of variables all moving in different ways in a complex system, how does a doctor bring all that information together and decide what to do? It is not possible to do this with the human mind; there are just too many variables. We have to do it with computers.”

The study, which analysed daily blood samples from 18 patients immediately before and in a week-long period after kidney transplants, produced a single “optimal reaction coordinate” from the thousands of variables. This was translated to a single number (on a continuous scale from 0 to 1) describing the likelihood of a patient’s state at any one time resulting in organ success or failure.

Dr Krivov said: “It is a bit like measuring GDP in the economy: a single number quantifying a huge amount of complex activity and allowing you to understand the dynamics of the system.”

He added: “One of the advantages is that the output is not binary. In the past, we have tended to make decisions based on certain physical parameters. Depending on the current value or a large movement in such an indicator, we have decided whether a patient is ‘healthy’ or ‘unhealthy’ and whether or not they require treatment. At the simplest level, that could be taking their temperature. The new approach describes the dynamics of the whole system and quantifies on a continuous scale where the patient is.”

Importantly, the technique does not depend on an understanding of the exact mechanism of kidney disease and is therefore, in principle, applicable in many other areas.

Dr Krivov said: “I am not a kidney specialist. I just need the data. I can then analyse it using the same equation we used here to describe the dynamics of a condition. This could be particularly powerful in areas where you are dealing with slowly developing and complex conditions, where you need to get away from a healthy-unhealthy dichotomy and engage with the incremental dynamics of the disease.”

Given enough data, the technique could even be used to quantify very complex and extended processes affecting the whole population and could, ultimately, change our way of seeing our health.

“It would require a lot of data and a lot of people regularly giving their data but there is nothing in theory to stop us applying this to something like age, for instance,” Dr Krivov said.

“If you are looking at biological aging, what is the best way to quantify it? You don’t just have two states: ‘old’ or ‘young’. It is a really slow process and it is certainly not described by your passport age. If we can quantify your age in a biological way, we can change the way you see your life and health. If you have a number describing it, you can see where you are speeding up biological aging and you can then work out ways to slow it down or even reverse it.”

###

Further information
Dr Sergei Krivov is available for interview.

Contact:
Chris Bunting, Senior Press Officer, University of Leeds; phone: +44 113 343 2049 or email .(JavaScript must be enabled to view this email address)

###

Share196Tweet123Share49
Urology Today

Urology Today

  • Trending
  • Comments
  • Latest
Low Rates of PSA Screening Linked to Increase in Metastatic Prostate Cancer

Low Rates of PSA Screening Linked to Increase in Metastatic Prostate Cancer

November 4, 2022

Urethral pressure profilometry

September 8, 2020
Embryogenesis -Paediatric Urology

Embryogenesis -Paediatric Urology

November 2, 2022

Genetic basis of genitourinary malformations

0
Embryogenesis -Paediatric Urology

Embryogenesis -Paediatric Urology

0
Upper urinary tract

Upper urinary tract

0
Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

Yoga for Prostate Cancer: Best Yoga exercises to combat prostate growth in men

November 14, 2022
New treatment can more than double life expectancy for people with prostate cancer: doctor

New treatment can more than double life expectancy for people with prostate cancer

November 14, 2022
Study finds that use of yoga app can reduce urinary incontinence

Study finds that use of yoga app can reduce urinary incontinence

November 9, 2022
Urology Today

Copyright © 2022 Urology Today.

Navigate Site

  • About
  • Advertise
  • Privacy & Policy
  • Contact

Follow Us

No Result
View All Result
  • Home
  • Featured Urology
    • Urologic Oncology
    • Female Urology
    • Pediatric Urology
    • What is Urology?
  • Lifestyle

Copyright © 2022 Urology Today.

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In