Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Vasodilator hormone improved kidney function & blood flow in PKD model

  • - Urology / Nephrology News
  • Dec 06, 2011
  • Comments
  • Viewed: 7691
Tags: | kidney disease | kidney function | niddk | pkd |

After a four-week course of the vasodilator hormone relaxin, kidney function and blood flow immediately improved in lab rats genetically altered to model polycystic kidney disease (PKD), a life-threatening genetic disorder, according to research presented on Dec. 6 at the American Society for Cell Biology Annual Meeting in Denver.

In addition to widening the blood vessels, relaxin lowered the collagen scores of the PKD rats, indicating that the drug had slowed scar formation or helped dissolve the old fibroid tissue that characterizes the kidneys of animals and humans with the disease, according to Heather Ward, Ph.D., and Angela Wandinger-Ness, Ph.D., of the University of New Mexico and collaborators.

PKD is a life-threatening genetic disorder that affects 600,000 Americans, according to the National Institute of Diabetes, Digestive, and Kidney Diseases (NIDDK). About 50% of individuals diagnosed with PKD develop end-stage renal disease by age 60.

The researchers also noted that in rats, relaxin reduced the size of the large fluid-filled cysts that gradually encroach on kidney function in human PKD patients.

PKD was the first disease to be recognized as a ciliopathy, a disorder characterized by defects in primary cilia, tiny hair-like structures that protrude from virtually every cell in the human body.

In the search of effective treatments, most PKD researchers have concentrated on halting or reversing PKD’s characteristic cyst formation.

Ward and her colleagues instead examined the non-cystic aspects of PKD progression, particularly the poor blood flow and extensive internal scarring called fibrosis that encroaches on the glomeruli, the vital clusters of looping blood vessels that filter wastes and excess water from the blood.

They decided to evaluate relaxin because the hormone is a powerful vasodilator. It was first identified in pregnant women but also occurs in men.

Prompted by the hormone’s positive effects on the PKD animals, Ward and colleagues explored the differences in kidney gene expression between relaxin and control-treated rats. The results of the gene expression analysis suggested that relaxin, in part, affects genes associated with epithelial trafficking.

The researchers said that they hypothesize that relaxin’s direct effect on signaling pathways of kidney fibroblasts and vascular cells improves the renal environment, indirectly affecting cystic epithelia and slowing cyst growth.



Heather Ward, Ph.D.
University of New Mexico
.(JavaScript must be enabled to view this email address)

William “Billy” Sparks
Media Relations
University of New Mexico
.(JavaScript must be enabled to view this email address).

John Fleischman
American Society for Cell Biology
.(JavaScript must be enabled to view this email address)
513-706-0212 (cell)

Cathy Yarbrough
American Society for Cell Biology
.(JavaScript must be enabled to view this email address)


Tuesday, Dec. 6, 2011
12:30 to 2 p.m.
Session: Post-Golgi Trafficking
Presentation 1628
Board Number: B475

This research is funded by the National Institutes of Health (NIH)/National Center for Research Resources 5P20RR016480-10 UNM; and IDeA Networks of Biomedical Research Excellence (INBRE) Scholarship and NIH/NIDDK R01DK50141-11A1. Ward has been awarded a grant from National Institute of General Medical Sciences.

Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]

Your details

* Required field

Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

robotic-assisted radical prostatectomy1 - diarrhea1 - berger's disease1 - vascular endothelial growth factor1 - nausea1 - high-precision surgical robot1 - sodium bicarbonate1 - lipiduria1 - sexual intercourse4 - genital tract1 - medullary cystic disease1 - end stage kidney disease1 - seminal vesicle stones1 - urinary reflux1 - advanced kidney disease2 - journal of rheumatology1 - resistant bacteria1 - clinical journal of the american society of nephrology4 - laparoscopic operations1 - lethal prostate cancer1 - intravenous injection1 - androgenic stimulation1 - kidney stone surgery1 - magnesium1 - surgical nephrectomy1 - niaid1 - walking1 - autoimmune kidney disorder1 - diet1 - jet1 -