Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Dartmouth researchers test safety of Nivolumab in kidney cancer

  • - Urology / Nephrology News
  • Jun 03, 2013
  • Comments
  • Viewed: 6792
Tags: | kidney cancer | renal cell carcinoma |

Researchers at Dartmouth-Hitchcock Norris Cotton Cancer Center will present a poster on a phase I clinical trial of Nivolumab, a PD-1 receptor blocking antibody, being used in combination with other drugs in patients with metastatic renal cell carcinoma (mRCC) at the ASCO Annual Meeting on June 3, 2013.

Metastatic renal cell carcinoma or kidney cancer is the seventh most common cancer, leading to approximately 116,000 deaths annually worldwide. In roughly one-quarter of those with mRCC, the cancer has already spread or metastasized at diagnosis.

Nivolumab is an immune checkpoint inhibitor being tested in many cancers such as advanced melanoma and nonsmall cell lung cancer. It helps the body fight renegade cancer cells by restoring normal T-cell antitumor function. T-cells are a type of white blood cell that act like soldiers by searching out and destroying invaders. Nivolumab accomplishes this by suppressing an immune checkpoint modulator.

In this study, Nivolumab will be used in combination with sunitinib, pazopanib (existing treatments), or ipilimumab. These existing treatments have shown to reduce progression of the disease, but without lasting or durable response. Many patients eventually develop resistance to them. In other Phase 1 and 2 clinical trials, Nivolumab has shown durable responses in patients with mRCC.

The ASCO poster session describes an ongoing four-arm Phase 1 dose-escalation and expansion study evaluating combinations of Nivolumab with sunitinib, pazopanib, or ipilimumab in patients with mRCC. The primary objectives are to assess safety and tolerability, and to determine the recommended Phase 2 dose in patients with mRCC. The secondary objective is to assess preliminary antitumor activity. Researchers will also evaluate overall survival, pharmacodynamics, predictive biomarkers for the combinations, pharmacokinetics and immunogenicity of Nivolumab.


Abstract No: TPS4593
Clinical Trial information: NCT01472081

About Norris Cotton Cancer Center at Dartmouth-Hitchcock

Norris Cotton Cancer Center combines advanced cancer research at Dartmouth College and the Geisel School of Medicine at Dartmouth College with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center, at Dartmouth-Hitchcock regional locations in Manchester, Nashua, and Keene, NH, and St. Johnsbury, VT, and at 12 partner hospitals throughout New Hampshire and Vermont. It is one of 41 centers nationwide to earn the National Cancer Institute’s “Comprehensive Cancer Center” designation.


Donna Dubuc
.(JavaScript must be enabled to view this email address)
Dartmouth-Hitchcock Medical Center

Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]

Your details

* Required field

Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

oab6 - diabetics1 - kidney disorder1 - glycosuria1 - american society nephrology1 - trabecular bone1 - renal tubular acidosis2 - renal ultrasonography1 - kidney tumours1 - treatment of prostate cancer1 - recurrent bladder infection1 - vagina4 - urate nephropathy1 - carboplatin1 - prostate disorders1 - renal pelvis1 - invasive treatment1 - lower urinary tract symptom score1 - mammogram1 - symptomatic stone event1 - lupus nephritis3 - urethral diverticula1 - sers1 - sex therapy1 - osteomalacia2 - tissue matching1 - clinical journal of the american society nephrology3 - hyperpnea1 - hormone-deprivation therapy1 - gonococcal infections1 -