Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Low cholesterol linked with worse survival in patients with kidney cancer

  • - Urology / Nephrology News
  • Jun 12, 2014
  • Comments
  • Viewed: 2322
Tags: | cholesterol | kidney cancer |

People are often told to reduce their cholesterol to improve their heart health, but new research suggests that low cholesterol may increase kidney cancer patients’ risk of dying from their disease. The findings, which are published in BJU International, indicate that cholesterol testing may help doctors as they monitor and treat patients with kidney cancer.

Increasing evidence suggests that alterations in cholesterol and other lipids are associated with the development, progression, and prognosis of various cancers. To assess the situation as it relates to kidney cancer, Tobias Klatte, MD, of the Medical University of Vienna in Austria, and his colleagues analyzed total blood cholesterol levels in 867 patients with renal cell carcinoma before they underwent kidney surgery. The investigators then followed the patients for a median of 52 months.

Low blood cholesterol before treatment was associated with more advanced tumor stages and cancer spread during follow-up. Also, patients with high cholesterol had a 43 percent lower risk of dying from their cancer compared with patients with low cholesterol. Finally, including patients’ cholesterol levels with traditional risk factors increased the accuracy of prognoses.

It’s unclear how cholesterol may affect a kidney cancer patients’ prognosis. It may be that certain components of cholesterol impact the activity of cancer-related pathways to affect tumor growth and spread.

“As this was a hypothesis-generating study, our findings should be confirmed in independent datasets. If confirmed, patients with low cholesterol may be considered high-risk and may be treated or followed up more aggressively,” said Dr. Klatte.


Evelyn Martinez
.(JavaScript must be enabled to view this email address)

Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]

Your details

* Required field

Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

burning2 - conventional ultrasound1 - docetaxel1 - collagen diseases1 - journal of the national cancer institute1 - cancerous tissue1 - journal of endourology1 - hormone-refractory prostate cancer2 - urinary tract disorder1 - clinical trials1 - uric acid7 - tissue matching1 - prostate1 - proton therapy1 - extracorporeal shockwave lithotripsy1 - vigorous activity1 - local anesthesia1 - persistent incontinence1 - renal carcinoma1 - prostate cancer drug2 - anxiety1 - generalized edema1 - testosterone6 - annual screening1 - urinary stasis1 - fibroids1 - impotence4 - renal vein1 - renal diabetes insipidus1 - gum disease1 -