Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Newly discovered protein may protect kidney cells from injury

  • - Urology / Nephrology News
  • Sep 02, 2015
  • Comments
  • Viewed: 4599
  
Tags: | acute kidney injury | kidney cells | kidney disease | kidney function |

A new discovery by Boston University School of Medicine (BUSM) researchers may change how kidney disease is treated in the future.

The previously unknown protein transmembrane and immunoglobulin containing 1 (TMIGD1) involved in protecting kidney epithelial cells (cells critical to normal kidney function) from injury, could be a novel target for restoring kidney function from various forms of kidney disease. The findings are published online in the American Journal of Pathology.

Kidneys have several roles, of which filtering blood of waste products to generate urine is the primary function. Kidneys can fail over days, known as acute kidney injury (AKI), or can develop over years, known as chronic kidney disease (CKD), an irreversible form of kidney failure. Both forms of kidney failure are common and represent a tremendous health care burden. Kidney failure among inpatients not only lengthens hospital stays but also indicates overall poor prognosis. Nearly 20 million people, or 10 percent, of the U.S. population suffers from CKD primarily from diabetes and hypertension, consuming approximately $32.8 billion of Medicare budget.

Researchers reduced expression of TMIGD1 in kidney epithelial cells and demonstrated that they become susceptible to cell injury, whereas increasing TMIGD1 expression protected these cells from injury. “This study demonstrates that by altering the function of TMIGD1, it is possible to reduce kidney epithelial cell death and possibly avoid the high incidence of kidney failure and morbidity associated with kidney injury,” explained corresponding author Nader Rahimi, PhD, associate professor of pathology and laboratory medicine at BUSM.

TMIGD1 belongs to a new class of proteins involved in cell-cell recognition. The first member of TMIGD1 called IGPR-1, was identified by the same group of researchers in early 2012. IGPR-1 is involved in tumor angiogenesis, or the development of new blood vessels.

“While dialysis and transplantation are considered the cornerstone of therapy for both forms of renal failure, none of these strategies directly targets the kidney proximal epithelial cells. Therapeutic agents that could protect these cells from death can prevent and retard renal damage, thus postponing dialysis or need for transplantation,” added study co-author Vipul Chitalia, MD, PhD, assistant professor of medicine at BUSM and a nephrologist at Boston Medical Center.

###

Funding for this study was provided in part by the National Institutes of Health through grant award numbers R21 CA191970 and R01 CA175382. Emad Arafa, a graduate student and Philip Bondzie, a postdoctoral fellow at Boston University, are the co-primary authors.

###

Kristen Perfetuo
.(JavaScript must be enabled to view this email address)
617-638-8484

JOURNAL
American Journal of Pathology

Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]




Comment
Your details

* Required field


Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

testis1 - turner syndrome3 - osteoporosis1 - harvard medical school2 - advanced renal disease1 - pomegranate juice1 - testosterone therapy1 - prostate cancer cells2 - ischaemic heart disease1 - melamine-induced kidney disease1 - genetic disorders1 - zetia1 - pathologic fracture1 - heart risk1 - kidney cancer subtypes1 - the scientific registry of transplant recipients1 - head of the division of urology1 - bacteriuria2 - hypercalciuria5 - external sphincter dyssynergia3 - low blood pressure1 - prostate cancer drug2 - abiraterone2 - johnson & johnson1 - abdominal radiograph1 - kidney-damaging treatments1 - urethral hypermobility4 - painful urination1 - ureters drain1 - routine antenatal sonography1 -