Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Oxygen in Tumours Predicts Prostate Cancer Recurrence

  • - Urology / Nephrology News
  • Apr 01, 2012
  • Comments
  • Viewed: 2416
Tags: | hypoxia | personalized cancer medicine | prostate cancer | radiation therapy |

Low oxygen levels in tumors can be used to predict cancer recurrence in men with intermediate-risk prostate cancer even before they receive radiation therapy.

The clinical research, led by radiation oncologists at the Princess Margaret Hospital (PMH) Cancer Program, University Health Network (UHN) is published online today in Clinical Cancer Research, a journal of the American Association for Cancer Research (doi: 10.1158/1078-0432.CCR-11-2711).

“We’ve not only shown that men do worse if they have low oxygen levels (hypoxia) in their prostate cancer, but that they also do worse over a shorter period of time,” says Dr. Michael Milosevic, radiation oncologist in the PMH Cancer Program, UHN. “These patients seem to develop cancer recurrence within only a few years of completing treatment.”

“This information could change the way prostate cancer is treated and goes a long way to ensuring that all patients receive the right treatment from the outset – based on their individual tumour,” says Dr. Milosevic, who is also a professor of radiation oncology at the University of Toronto. “At the heart of it, this is what personalized medicine is all about.”

Prostate cancer is commonly treated with surgery or radiation therapy, and yet cancer recurs or spreads in about 25% of treated men. The discovery of indicators, such as low oxygen in tumours, enables doctors to better select the most appropriate and effective treatments for each patient even before radiation therapy is delivered.

Dr. Milosevic and colleagues measured oxygen levels in 247 men with localized prostate cancer prior to radiation therapy and followed them for a median of 6.6 years. Low oxygen in the tumors predicted early relapse after radiation treatment. It was also the only identified factor that predicted local recurrence during follow-up.

“We believe that a tumour’s genetic signature will be another promising predictor of recurrence,” says Dr. Robert Bristow, radiation oncologist in the PMH Cancer Program, UHN, and professor in the departments of radiation oncology and medical biophysics at the University of Toronto. “Combined, these indicators may signal that the cancer has spread at a previously-undetectable level.”

Dr. Milosevic and colleagues hope that identifying the factors that influence prostate cancer behavior will lead to the exploration of new drugs to target hypoxia in tumors. The findings may also accelerate the development of new treatment strategies – informing physicians when complementary treatment may be more effective. .

“Knowing what works for which patient will make treatment more effective and improve outcomes for patients,” says Dr. Milosevic.

The research was funded by United States Army Prostate Cancer Research Program, Terry Fox Program Project Grant through the National Cancer Institute of Canada and Terry Fox Foundation New Frontiers Program Project Grant through the Canadian Cancer Society Research Institute. Dr. Milosevic’s research is also supported by The Princess Margaret Hospital Foundation.

# # #

About Princess Margaret Hospital
Princess Margaret Hospital and its research arm, Ontario Cancer Institute, have achieved an international reputation as global leaders in the fight against cancer and delivering personalized cancer medicine. Princess Margaret Hospital, one of the top five international cancer research centres, is a member of the University Health Network, which also includes Toronto General Hospital, Toronto Western Hospital and Toronto Rehabilitation Institute.


Source: University Health Network (UHN)

Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]

Your details

* Required field

Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

prostate inflammation1 - erythrocyte casts1 - renal abnormalities1 - severe lower urinary tract symptoms1 - aggressive bladder tumors1 - metanephric blastema1 - hypertensive nephropathy1 - androgen receptor1 - transurethral resection1 - kidney disorder1 - fetal bladder1 - ultrasound1 - chlamydia trachomatis2 - triamterene stones1 - urinary arsenic1 - symptomatic kidney stones1 - prostate disorders1 - regional lymph nodes1 - sexual intimacy1 - mucosal irritation1 - advanced kidney disease2 - obturator canal1 - lower urinary tract8 - acute kidney injury8 - silicate stones1 - bartholin's cyst1 - levator hiatus1 - creatinine2 - nausea1 - voiding diary3 -