Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Hereditary Renal Diseases

  • - General Urology - Common Urological Problems - Medical Renal Disease
  • Jul 29, 2010
  • Comments
  • Viewed: 34266
  
Tags: | alport disease | chronic hereditary nephritis | hereditary renal diseases | medullary cystic disease |

The importance of inheritance and the familial incidence of disease warrant the inclusion of a classification of hereditary renal diseases. Although relatively uncommon in the population at large, hereditary renal disease must be recognized to permit early diagnosis for detection and genetic counseling.

Chronic Hereditary Nephritis
Evidence of the disease usually appears in childhood, with episodes of hematuria. Renal insufficiency commonly develops in males but only rarely in females. Survival beyond age 40 is rare.

In many families,  deafness and abnormalities of the eyes accompany the renal disease (so-called Alport disease).  Another form of the disease is accompanied by polyneuropathy. Infection of the urinary tract is a common complication.

There is splitting and thickening of the GBM or podocyte proliferation and thickening of Bowman’s capsule.  Recently,  kindreds have been described that have “thin-membrane disease.” This condition is characterized by microscopic hematuria and, often, later progression to chronic renal failure. This, like Alport disease, may represent inherited abnormalities or deficiencies in type IV collagen in the GBM. This affects both genders.

Diagnosis of Medical Renal Disease

Medical Renal Disease

Laboratory findings with these conditions are commensurate with existing renal function.  Treatment is symptomatic.

Cystic Diseases of the Kidney
Congenital structural anomalies of the kidney must be considered in any patient with hypertension, pyelonephritis,  or renal insufficiency.  Many of these patients are at increased risk of urinary tract infection.

A. Polycyctic Kidneys
Polycystic kidney disease is familial and often involves not only the kidney but the liver and pancreas as well.  It is clear that at least 2 genetic loci can lead to autosomal dominant polycystic kidney disease.

Page 1

1 2 Next »



Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]




Comment
Your details

* Required field


Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

martius flap1 - prostate cancer recurrence1 - immunosuppressive therapy1 - lupus nephritis3 - chemotherapy12 - head of the division of urology1 - early kidney disease1 - uterine fibroids1 - hormone treatment1 - teen pregnancy1 - klinefelter's syndrome1 - uric acid7 - cardiovascular disease5 - risk of kidney failure1 - renal tubules1 - journal of the national cancer institute1 - klotho hormone1 - hyperlipidemia1 - syphilis1 - cancerous prostate cells1 - placebo1 - hemodialysis11 - kit kat1 - robotic prostatectomy1 - kidney care1 - surgery and radiation therapy1 - vascular endothelial growth factor1 - phospho-proteomics1 - dysmorphia1 - ketogenic diet1 -