Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Mayo Clinic-Led Study Identifies Biomarkers for Early Risk Assessment of Acute Kidney Injury

  • - Urology / Nephrology News
  • Feb 06, 2013
  • Comments
  • Viewed: 7181
  
Tags: | acute kidney injury | early risk assessment | kidney injury | kidney injury risk |

Acute kidney injury strikes large numbers of hospitalized patients, including those with no prior kidney-related illness, and is one of the most costly and deadly conditions affecting critically ill patients. Findings published today in Critical Care from a Mayo Clinic-led, multicenter study identify two biomarkers of acute kidney injury that can be easily measured in urine and detect affected patients roughly 12 to 36 hours earlier than current tests.

“Failure to recognize and manage acute kidney injury in the early stages can lead to devastating outcomes for patients and increased costs to the health care system. Unfortunately, current blood and urine tests are not able to detect it early enough to avoid further complications or provide any chance for intervention,” says lead author Kianoush B. Kashani, M.D., a nephrologist and intensivist at Mayo Clinic.

The study’s findings give physicians a tool to determine early on whether a patient is at risk, Dr. Kashani says.

Researchers evaluated nearly 340 biomarkers to find the two with the highest correlation to kidney injury risk. The markers, Insulin Growth Factor Binding Protein-7 (IGFBP-7) and Tissue Inhibitor of Metalloproteinases-2 (TIMP-2), were later validated by another multicenter study known as the Sapphire Trial.

The study was sponsored by Astute Medical, Inc.

###
About Mayo Clinic

Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit MayoClinic.com or MayoClinic.org/news.

Journalists can become a member of the Mayo Clinic News Network for the latest health, science and research news and access to video, audio, text and graphic elements that can be downloaded or embedded.

###
Rebecca Eisenman
507-284-5005 (days)
507-284-2511 (evenings)
.(JavaScript must be enabled to view this email address)

Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]




Comment
Your details

* Required field


Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

pyelocaliceal diverticula1 - glucose assorption1 - pelvic viscera1 - vesicular stomatitis virus1 - radical nephrectomy4 - urorectal1 - transurethral resection1 - hyperuricosuria2 - adg1 - conners parent rating scale-revised1 - swelling1 - embryonic urothelium1 - prostate treatment system1 - kidney's artery1 - rsna1 - effective treatment of prostate cancer1 - bss1 - sodium2 - prostate cance1 - sexual satisfaction1 - organ procurement and transplantation network1 - nephrolithiasis2 - local recurrence1 - kidney tissue2 - catheters1 - proton therapy1 - bladder regeneration1 - urinary oxalate1 - ufe1 - urethral stones1 -