Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Polycystic Kidney Disease

A new target in polycystic kidney disease

In work suggesting a new approach to treating polycystic kidney disease (PKD), a leading cause of kidney failure, researchers at Children’s Hospital Boston were able to block the formation of fluid-filled cysts, the hallmark of the disease, in a mouse model. Their findings, using a compound that inhibits a receptor known as c-Met, will… A new target in polycystic kidney disease   



UCSB Scientists Discover New Drug Target for Kidney Disease

Two discoveries at UC Santa Barbara point to potential new drug therapies for patients with kidney disease. The findings are published in this week’s issue of the Proceedings of the National Academy of Sciences.

Over 600,000 people in the U.S., and 12 million worldwide, are affected by the inherited kidney disease known as autosomal-dominant… UCSB Scientists Discover New Drug Target for Kidney Disease   



Aurora A may contribute to kidney disease

The Aurora A kinase may contribute to polycystic kidney disease (PKD) by inactivating a key calcium channel in kidney cells, according to a study in the June 13 issue of The Journal of Cell Biology.

Aurora A is an oncogene best known as a regulator of mitotic progression. But the kinase has important functions… Aurora A may contribute to kidney disease   



Single gene controls development of many forms of polycystic disease

A single gene is central in the development of several forms of polycystic kidney and liver disease, Yale School of Medicine researchers report in the June 19 issue of Nature Genetics.

The findings suggest manipulating activity of PKD1, the gene causing the most common form of polycystic kidney disease, may prove beneficial in reducing… Single gene controls development of many forms of polycystic disease   



Vasodilator hormone improved kidney function & blood flow in PKD model

After a four-week course of the vasodilator hormone relaxin, kidney function and blood flow immediately improved in lab rats genetically altered to model polycystic kidney disease (PKD), a life-threatening genetic disorder, according to research presented on Dec. 6 at the American Society for Cell Biology Annual Meeting in Denver.

In addition to widening the… Vasodilator hormone improved kidney function & blood flow in PKD model   



New approaches in treating complicated childhood polycystic kidney disease

A collaborative team of physician-scientists at the Medical College of Wisconsin (MCW) and Children’s Hospital of Wisconsin Research Institute has developed a new evidence-based, clinical algorithm to help physicians treat complex patients with autosomal recessive polycystic kidney disease (ARPKD).

Their invited manuscript, written by Grzegorz Telega, M.D., associate professor of pediatrics (gastroenterology and hepatology)… New approaches in treating complicated childhood polycystic kidney disease   



Patients with a certain form of kidney disease may have a reduced risk of cancer

Patients with a certain form of kidney disease may have a reduced risk of cancer compared with patients with other kidney diseases, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Polycystic kidney disease (PKD) is a kidney disorder passed down through families… Patients with a certain form of kidney disease may have a reduced risk of cancer   



New treatment for polycystic kidney disease

Published in the Journal of the American Society of Nephrology, the treatment, which involves targeting tiny blood and lymphatic vessels inside the kidneys, is shown to improve renal function and slow progression of disease in mice.

Polycystic kidney disease (PKD) is a genetic disorder where fluid filled cysts grow in kidneys and destroy normal… New treatment for polycystic kidney disease   



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