Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Kidney Failure

How to Improve Health and Reduce Risk for Dialysis Patients

1. Depression Symptoms and Low Physical Activity May Keep Dialysis Patients from Working
Efforts to Improve Mood and Activity Might Help Patients Remain Employed

Many patients with kidney failure employed during the year before beginning dialysis are no longer employed early in their first year of treatment. A recent survey… How to Improve Health and Reduce Risk for Dialysis Patients   



Specific kidney cell could be key in the treatment of kidney failure in diabetes

Diabetes is the leading reason for kidney failure in the world, resulting in patients requiring dialysis or kidney transplantation. New research has found a cell in the kidney called the podocyte could be the key to understanding why this happens.

The study led by Dr Richard Coward, in the School of Clinical Sciences at… Specific kidney cell could be key in the treatment of kidney failure in diabetes   



Scientists learn more about how kidneys fail and how new drugs may intervene

Scientists are learning more about how protein gets in the urine when the kidneys begin to fail and how a new drug blocks it.

“We have known for a long time that renal failure comes with protein in your urine, especially in diabetes,” said Dr. David Pollock, renal physiologist at the Medical College of… Scientists learn more about how kidneys fail and how new drugs may intervene   



Starting dialysis too early can increase risk of death

Patients who are starting dialysis too early are at an increased risk of death, found an article in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/embargo/cmaj100349.pdf.

Glomerular filtration rate (eGFR) is a test that describes the flow rate of fluid going through the kidneys and is associated with early dialysis initiation. Current… Starting dialysis too early can increase risk of death   



Gene Mutation Play a Major Role in One Cause of Kidney Disease

Mutations in a gene called INF2 are by far the most common cause of a dominantly inherited condition that leads to kidney failure, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results may help with screening, prevention, and therapy.

Focal segmental glomerulosclerosis (FSGS)… Gene Mutation Play a Major Role in One Cause of Kidney Disease   



Canadian researchers discover new way to prevent infections in dialysis patients

Researchers have discovered that a drug used to treat dialysis catheter malfunction in kidney dialysis patients may now also help prevent both malfunction as well as infections.

Dr. Brenda Hemmelgarn from the University of Calgary Faculty of Medicine and her colleague Dr. Nairne Scott-Douglas, both members of the Libin Cardiovascular Institute of Alberta, undertook… Canadian researchers discover new way to prevent infections in dialysis patients   



Low Carbohydrate Diet May Reverse Kidney Failure in People with Diabetes

Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. They also identified a previously unreported panel of genes associated with diabetes-related kidney failure, whose expression was… Low Carbohydrate Diet May Reverse Kidney Failure in People with Diabetes   



TGen findings contribute to understanding of diabetic kidney disease

A gene called PVT1 may help reduce the kidneys ability to filter blood, leading to kidney disease, kidney failure and death, according to a study published today by researchers at the Translational Genomics Research Institute (TGen).

The TGen team found PVT1 expression levels increased up to 5-fold in response to hyperglycemia, or high blood… TGen findings contribute to understanding of diabetic kidney disease   



UCSB Scientists Discover New Drug Target for Kidney Disease

Two discoveries at UC Santa Barbara point to potential new drug therapies for patients with kidney disease. The findings are published in this week’s issue of the Proceedings of the National Academy of Sciences.

Over 600,000 people in the U.S., and 12 million worldwide, are affected by the inherited kidney disease known as autosomal-dominant… UCSB Scientists Discover New Drug Target for Kidney Disease   



Aboriginal children less likely to receive kidney transplants

Aboriginal children with kidney failure were less likely to receive a kidney transplant compared to white children, found an article in CMAJ (Canadian Medical Association Journal) (pre-embargo link only).

Compared with non-Aboriginal people, Aboriginal adults with kidney failure in Canada have lower rates of kidney transplantation, the best treatment for kidney failure.… Aboriginal children less likely to receive kidney transplants   



Student Team Invents Device to Cut Dialysis Risk

Johns Hopkins University graduate students have invented a device to reduce the risk of infection, clotting and narrowing of the blood vessels in patients who need blood-cleansing dialysis because of kidney failure.

The device, designed to be implanted under the skin in a patient’s leg, would give a technician easy access to the patient’s… Student Team Invents Device to Cut Dialysis Risk   



IV fluids may reduce severity of kidney failure in kids with E. coli infection

Infection with E. coli bacteria can wreak havoc in children, leading to bloody diarrhea, fever and kidney failure.

But giving children intravenous fluids early in the course of an E. coli O157:H7 infection appears to lower the odds of developing severe kidney failure, according to researchers at Washington University School of Medicine in St.… IV fluids may reduce severity of kidney failure in kids with E. coli infection   



Simple Urine Test Detects Silent Kidney Disease

A simple and inexpensive urine test routinely done in family doctors’ offices may be the key to identifying individuals who are silently undergoing rapid kidney function decline, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). Using this test could lead to potentially earlier and… Simple Urine Test Detects Silent Kidney Disease   



Scientists make strides toward drug therapy for inherited kidney disease

Scientists at UC Santa Barbara have discovered that patients with an inherited kidney disease may be helped by a drug that is currently available for other uses. The findings are published in this week’s issue of the Proceedings of the National Academy of Sciences.

Over 600,000 people in the U.S., and 12 million worldwide,… Scientists make strides toward drug therapy for inherited kidney disease   



Why some kidney disease patients can’t repair blood vessels

In some kidney diseases, patients have high blood levels of a protein that blocks blood vessel repair, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). Inhibiting the protein may reduce patients’ risk of developing kidney failure.

Patients with an autoimmune kidney disorder called anti-neutrophil… Why some kidney disease patients can’t repair blood vessels   



Research aims to prevent diabetic kidney failure

The enzyme arginase-2 plays a major role in kidney failure, and blocking the action of this enzyme might lead to protection against renal disease in diabetes, according to researchers.

“We believe these arginase inhibitors may be one of the new targets that can slow down the progression of, or even prevent the development of,… Research aims to prevent diabetic kidney failure   



Racial inequalities exist for kids with kidney disease

Among children with kidney disease, certain races are less likely to get kidney transplants and are more likely to die than other races, according to two studies from Emory University that were presented during the American Society of Nephrology’s Annual Kidney Week.

Kidney transplantation is the optimal treatment for patients with kidney failure, but… Racial inequalities exist for kids with kidney disease   



BUSM researchers develop blood test to detect membranous nephropathy

Research conducted by a pair of physicians at Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) has led to the development of a test that can help diagnose membranous nephropathy in its early stages. The test, which is currently only offered in the research setting and is awaiting commercial development, could… BUSM researchers develop blood test to detect membranous nephropathy   



Kidney failure risk higher for liver transplant patients following allocation policy change

Research from the University of Michigan Health System shows the risk for kidney failure among liver transplant recipients is higher following the implementation of Model of End Stage Liver Disease (MELD), a policy change in 2002 that altered how liver transplant allocation is decided.

The study, led by Pratima Sharma, M.D., M.S., an assistant… Kidney failure risk higher for liver transplant patients following allocation policy change   



Proteins may warn of diabetic kidney disease risk

A simple blood test might reveal which people with diabetes are most prone to kidney failure, two long-term studies show. An abundance of two compounds better known as culprits in inflammation seems to pinpoint high-risk diabetes patients years before they show outward signs of kidney problems, researchers say.

Both studies linked high levels of… Proteins may warn of diabetic kidney disease risk   



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