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Common Urological Problems

Renal Involvement in Collagen Diseases

  • - General Urology - Common Urological Problems - Medical Renal Disease
  • Jul 29, 2010
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Tags: | collagen diseases | glomerulonephritis | henoch-schönlein purpura | lupus erythematosus |

Although it may not be accurate to classify all of these disorders as collagen diseases, disseminated lupus erythematosus, polyarteritis nodosa, microscopic angiitis scleroderma, Wegener’s granulomatosis,  Henoch-Schönlein purpura and thrombotic thrombocytopenic purpura have been implicated in cases of glomerulonephritis.

The urine sediment is often diagnostic,  containing erythrocytes and erythrocyte casts; renal tubular cells, including some filled with fat droplets; and waxy and granular broad casts. The presence of these formed elements is indicative of active glomerular and tubular disease.

The symptoms and signs of the primary disease,  involving extrarenal findings (eg, pulmonary or ear, nose, or throat changes with Wegener’s granulomatosis;  dermatologic abnormalities or carditis with systemic lupus erythematosus; dysphagia with scleroderma), as well as the presence of ANCA and other serologic tests, help to differentiate the form of collagen disease present.

Complete renal recovery from the disease is not likely to occur, although steroid and immunosuppressive drugs (alone or in combination) may be effective for longterm amelioration.

Diagnosis of Medical Renal Disease

Medical Renal Disease

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Flavio G. Vincenti, MD, & William J.C. Amend, Jr., MD

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REFERENCES

  1. Adler S: Diabetic nephropathy: Linking histology, cell biology, and genetics. Kidney Int 2004;66:2095.
  2. Alric L et al: Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN. Am J Kidney Dis 2004;43:617.
  3. Appel GB et al: Membranoproliferative glomerulonephritis Type II (dense deposit disease): An update. J Amer Soc Neph 2005;16: 1392.
  4. Barratt J, Feehally J: IgA nephropathy. J Amer Soc Neph 2005;16: 2088.
  5. Braden GL et al: Tubulointerstitial diseases. Am J Kidney Dis 2005; 46:560.
  6. Buhaescu I et al: Systemic vasculitis: Still a challenging disease. Am J Kidney Dis 2005;46:173.
  7. Chesney R: The changing face of childhood nephrotic syndrome. Kidney Int 2004;66:1294.
  8. Flanc RS et al: Treatment of diffuse proliferative lupus nephritis: A meta-analysis of randomized controlled trials. Am J Kidney Dis 2004;43:197.
  9. Couser WG (guest editor): Frontiers in nephrology: Membranous nephropathy. J Amer Soc Neph 2005;16:1184.
  10. Ginzler EM et al: Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N Engl J Med 2005;353:2219.
  11. Grantham JJ: Advancement in the understanding of polycystic kidney disease: A system approach. Kidney Int 2003;64: 1154.
  12. Heering P et al: Cyclosporine A and chlorambucil in the treatment of idiopathic focal segmental glomerulosclerosis. Am J Kidney Dis 2004;43:10.
  13. Hruska KA: Treatment of chronic tubulointerstitial disease: A new concept. Kidney Int 2002;61:1911.
  14. Imaging the Kidney-Radiologic Imaging 2006. (Excerpts) Nephron Clin Pract 2006;103:c19.
  15. Izzedine H et al: Oculorenal manifestations in systemic autoimmune diseases. Am J Kidney Dis 2004;43:209.
  16. Javaid B, Quigg RJ: Treatment of glomerulonephritis: Will we ever have options other than steroids and cytotoxics? Kidney Int 2005;67:1692.
  17. Nair R, Walker PD: Is IgA nephropathy the commonest primary glomerulopathy among young adults in the USA? Kidney Int 2006;69:1455.
  18. Noris M, Remuzzi G: Hemolytic uremic syndrome. J Amer Soc Neph 2005;16:1035.
  19. Perna A et al: Immunosuppressive treatment for idiopathic membranous nephropathy: A systematic review. Am J Kidney Disease 2004;44:385.
  20. Rosner MH, Bolton WK: Renal function testing. Am J Kidney Dis 2006;47:174.
  21. Rossert J: Drug-induced acute interstitial nephritis. Kidney Int 2001; 60:804.
  22. Tenenhouse HS, Murer H: Disorders of renal tubular phosphate transport. J Am Soc Neph 2003;14:240.
  23. Troyanov S et al: Renal pathology in idiopathic membranous nephropathy: A new perspective. Kidney Int 2006;69:1641.
  24. Wilmer WA et al: Management of glomerular proteinuria: A commentary. J Amer Soc Neph 2003;14:3217.

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