Urology Today.net

Site updated at Thursday, 12 May 2016

Common Urological Problems

Hereditary Renal Diseases

  • - General Urology - Common Urological Problems - Medical Renal Disease
  • Jul 29, 2010
  • Comments
  • Viewed: 30741
  
Tags: | alport disease | chronic hereditary nephritis | hereditary renal diseases | medullary cystic disease |

The importance of inheritance and the familial incidence of disease warrant the inclusion of a classification of hereditary renal diseases. Although relatively uncommon in the population at large, hereditary renal disease must be recognized to permit early diagnosis for detection and genetic counseling.

Chronic Hereditary Nephritis
Evidence of the disease usually appears in childhood, with episodes of hematuria. Renal insufficiency commonly develops in males but only rarely in females. Survival beyond age 40 is rare.

In many families,  deafness and abnormalities of the eyes accompany the renal disease (so-called Alport disease).  Another form of the disease is accompanied by polyneuropathy. Infection of the urinary tract is a common complication.

There is splitting and thickening of the GBM or podocyte proliferation and thickening of Bowman’s capsule.  Recently,  kindreds have been described that have “thin-membrane disease.” This condition is characterized by microscopic hematuria and, often, later progression to chronic renal failure. This, like Alport disease, may represent inherited abnormalities or deficiencies in type IV collagen in the GBM. This affects both genders.

Diagnosis of Medical Renal Disease

Medical Renal Disease

Laboratory findings with these conditions are commensurate with existing renal function.  Treatment is symptomatic.

Cystic Diseases of the Kidney
Congenital structural anomalies of the kidney must be considered in any patient with hypertension, pyelonephritis,  or renal insufficiency.  Many of these patients are at increased risk of urinary tract infection.

A. Polycyctic Kidneys
Polycystic kidney disease is familial and often involves not only the kidney but the liver and pancreas as well.  It is clear that at least 2 genetic loci can lead to autosomal dominant polycystic kidney disease.

Page 1

1 2 Next »



Bookmark and Share

Post a comment [ + Comment here + ]

There are no comments for this entry yet. [ + Comment here + ]




Comment
Your details

* Required field


Please enter the word you see in the image below:

Comments are moderated by our editors, so there may be a delay between submission and publication of your comment. Offensive or abusive comments will not be published.

sexual changes1 - urogenital sphincter1 - hexagonal crystals1 - hesitancy2 - prostate surgery4 - rectocele5 - ultrasonic wave1 - sex after prostate surgery1 - mortality1 - glucose assorption1 - pregnancy7 - prostate cancer treatment5 - diabetic nephropathy6 - bicycling1 - fred hutchinson cancer research center1 - cnc1 - bladder cancer8 - xanthine oxidase1 - urinary excretion1 - pain1 - advanced ckd1 - nephrons2 - membranoproliferative glomerulonephritis2 - university of california san francisco1 - female urinary tract1 - bladder control4 - distal tubule1 - robot-assisted surgery1 - sudden cardiac death2 - kidney-damaging treatments1 -